Miscarriage Prevention Blog Series Part 1: Testing

Pregnancy loss can be deeply emotional and confusing, and many people are left wondering why it happened and what they can do next. This blog series is here to guide you through understanding the potential causes of miscarriage, the tests that can help, and practical steps to support your fertility and prepare for a healthy pregnancy.

Part 1: Miscarriage Causes and Diagnostic Tests You Should Know About

What Testing Should I Have Done After a Miscarriage?

After experiencing a miscarriage, understanding what might have contributed can help you feel more empowered and guide the next steps for a healthy pregnancy. Diagnostic testing provides valuable insights into hormonal, metabolic, autoimmune, and nutritional factors that can impact early pregnancy.

Note- not all of these tests are indicated for everyone. Talk to your doctor about the following tests:

Thyroid Health and Miscarriage Risk

  • Tests: TSH, Free T4, ± Free T3
  • Importance: Thyroid dysfunction, even mild, can increase miscarriage risk
  • Anti-TPO antibodies: Higher risk even if thyroid levels are normal
  • Optimal preconception TSH: 0.5–2.5 mIU/L

Hormone and Metabolic Testing for Fertility

  • Tests: Fasting glucose, insulin, HbA1c, lipid panel, LH, FSH, estradiol, total & free testosterone, DHEA-S, mid-luteal progesterone
  • Why: PCOS, insulin resistance, or luteal phase defects can impact fertility and early pregnancy outcomes
  • Note: Mid-luteal progesterone <10 ng/mL may indicate luteal phase defect

Autoimmune and Blood Disorders Linked to Pregnancy Loss

  • Tests: Antiphospholipid antibody panel, ANA, celiac serology
  • Why: Conditions like APS or untreated celiac disease can increase miscarriage risk

Nutritional Deficiencies That Can Increase Miscarriage Risk

  • Tests: Vitamin D, ferritin, B12, homocysteine
  • Why: Deficiencies or elevated markers of inflammation can impact early pregnancy

When to Consider Advanced Testing or Specialist Referral

  • ≥2 consecutive pregnancy losses with abnormal findings
  • APS, thyroid autoimmunity, metabolic or endocrine abnormalities

Next: Learn how nutrition and lifestyle choices can support a healthy pregnancy after miscarriage.

Disclaimer: This article is for informational purposes only and is not medical advice. Consult with a healthcare provider before making significant changes to your caffeine consumption, especially if you have underlying health conditions.

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